Abstract
BackgroundDespite tremendous developments in synthetic medicine, medicinal plants are still commonly used for the management of diabetes mellitus. This study synthesized scientific evidence on commonly used medicinal plants for the management of diabetes mellitus (DM) in Ethiopia.MethodsDatabases (PubMed, Cochrane, CINAHL and Google Scholar) have been thoroughly sought and evidence was synthesized.ResultsThirty studies conducted anti-diabetic activities studies on 19 medicinal plants in Ethiopia. Most of the studies were in vivo studies (25). Others include; clinical study (1), in vitro studies (2), and both in vivo and in vitro study (2). Trigonella foenum-graecum L., clinical study, showed an improved lipid profile in type II diabetic patients. Comparable blood sugar level (BSL) lowering effect to glibenclimide was observed with Persea Americana and Moringa stenopetala. Noteworthy in vitro half maximal inhibitory concentration (IC 50) of Aloe megalacantha B and Aloe monticola R were observed. Animal model studies demonstrated the relative safety of the plants extract and phytochemistry studies showed various components.ConclusionMedicinal plants used for management of diabetes mellitus in Ethiopia are worthy for further study for pharmacologically active ingredients and clinical evaluation.
Highlights
Despite tremendous developments in synthetic medicine, medicinal plants are still commonly used for the management of diabetes mellitus
Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia due to impaired insulin secretion, defective insulin action or both
With a lack of critical appraisal on the currently evidence studies, this study aimed at reviewing information on the reported scientific evidence for effectiveness of medicinal plans used in Ethiopia in the management of diabetes mellitus (DM)
Summary
Despite tremendous developments in synthetic medicine, medicinal plants are still commonly used for the management of diabetes mellitus. This study synthesized scientific evidence on commonly used medicinal plants for the management of diabetes mellitus (DM) in Ethiopia. Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia due to impaired insulin secretion, defective insulin action or both. Chronic hyperglycemia is associated with long term microvascular complications affecting the cardiovascular, eyes, kidneys, and nerves [1]. Herbal medicines could provide an alternative management. Compromised effectiveness, cost, accessibility, affordability, and tolerability are some of the limitations of current conventional anti-diabetic medicine. African medicinal plants are commonly used in the management of DM and provide an alternative therapy. Research is required on different indigenous plant and herbal formulations. The research will shed (2021) 7:16 light on effectiveness and safety of herbal medicines. The findings will help to discover novel drugs and/or optimize the traditional use
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