Efficacy of two kinds of eye drops in stabilizing tear film and relieving dry eye after cataract surgery

Abstract

Objective To compare the efficacy of recombinant bovine basic fibroblast growth factor (rb-bFGF) eye drops and hypromellose 2910 dextran 70 and glycerol eye drops in maintaining the tear film stability and relieving dry eye symptoms after age-related cataract surgery. Methods The data of 131 eyes of 100 patients with age-related cataract were selected, and they were divided randomly into the rb-bFGF group, 64 eyes of 50 cases; and the hydroxyl indican group, 67 eyes of 50 cases. All patients underwent phacoemulsification combined with intraocular lens implantation. After surgery, rb-bFGF group were treated with rb-bFGF eye drops and the hydroxyl indican group were treated with hydroxyl indican eye drops. All patients were followed up for 3 months, and efficacy were compared between the two groups. Results The schirmer I test (SIT) in rb-bFGF group 3 months after surgery was (14.47±4.69)mm and the break-up time (BUT) was(13.96±2.84)s, in hydroxyl indican group was (12.03±4.76) mm and (12.35±3.27) s. The difference were significant between the two groups (P=0.004, 0.003). The scores of cornea fluorescein staining (CFS) and dry eye symptoms in rb-bFGF group were significantly lower than those in hydroxyl indican group(P=0.011, 0.000). Conclusion Both rb-bFGF eye drops and hydroxyl indican eye drops can prolong BUT, improve tear film stability, relieve dry eye symptoms, and promote the repair and regeneration of corneal epithelial cells after age-related cataract surgery. Rb-bFGF eye drops have better effects. Key words: Cataract, age-related; Phacoemulsification; Lens, intraocular; Eye drops, recombinant bovine basic fibroblast growth factor (rb-bFGF), hypromellose 2910, dextran 70 and glycerol