Efficacy of three dimensional conformal radiotherapy combined with TP chemotherapy on patients with mid-stage and advanced esophageal cancer

Abstract

Objective To investigate the efficacy of TP chemotherapy (nedaplatin+ paclitaxel) combined with three-dimensional conformal radiotherapy on patients with mid-stage and advanced esophageal cancer. Methods A total of 83 patients with advanced esophageal cancer were selected and divided into two groups according to the different treatment method, 41 cases in the control group were treated by three dimensional conformal radiotherapy, and 42 cases in the study group were treated by TP chemotherapy based on the control group. The efficacy, quality of life (SF-36), and the incidence of adverse reactions were compared between the two groups. The levels of serum cytokeratin 19 fragment antigen 21-1 (CYFRA21-1), carbohydrate antigen 125 (CA125) and carcinoembryonic antigen (CEA) in the two groups before and after therapy were compared. Results The total effective rate of the study group (69.05%) was higher than that of the control group (46.34%), the difference was significant(P 0.05). Conclusions TP chemotherapy combined with three dimensional conformal radiotherapy is effective on advanced esophageal cancer, which can significantly reduce the levels of serum tumor markers and improve their quality of life and the safety is high. Key words: Three-dimensional conformal radiotherapy; TP chemotherapy scheme; Esophageal cancer; Quality of life