Abstract
Objective To determine the efficacy of tamoxifen vs letrozole during freeze-thaw embryo transfer (FET) in patients with thin endometrium. Methods A total of 85 patients with thin endometrium visited in our hospital from June 2014 to December 2016 were collected and received FET. All the patients were divided into two groups according to different ovulation regimens: the study group (n=40) treated with tamoxifen, and the control group (n=45) with letrozole. The levels of serum estradiol (E2) , progesterone and endometrial thickness were measured in both groups on the day of human chorionic gonadotropin (HCG) and day of FET. The outcome of the two groups was compared. Results Serum E2 levels (both P 0.05) , were significantly greater in the study group than those in control group on the days of HCG and FET. Significantly less time for endometrial preparation was needed in the study group as compared with the control group[ (13.18±2.87) d vs (16.25±3.46) d, P 0.05) . Conclusion The use of tamoxifen during FET in patients with thin endometrium may increase the serum levels of E2 on days of HCG and FET, with less time needed for endometrial preparation. Key words: Thin endometrium; Frozen-thawed embryo transfer; Letrozole; Tamoxifen; Treatment outcome
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