Clinical outcome of frozen-thawed embryo transfer in patients with polycystic ovary syndrome

Abstract

Objective To investigate the influencing factors of frozen-thawed embryo transfer and the value of blastocyst transfer after whole embryos cryopreservation in PCOS patients. Methods Six hundred and seventy patients underwent embryo transfer for the first time due to PCOS factors were divided into 3 groups according to embryo transfer cycle and stage of embryo development: group A, 314 patients with frozen-thawed D3 embryo transfer; group B, 155 patients with fresh D3 embryo transfer; group C, 201 patients with frozen-thawed blastocyst transfer. Results The clinical pregnancy rate, implantation rate and multiple pregnancy rate were significant lower in group A than those in group C(P<0.05). The clinical pregnancy rate, implantation rate, multiple pregnancy rate and live birth rate was significant lower in group A than those in group C(P<0.05). Conclusions PCOS patients with frozen-thawed D3 embryo transfer is associated with a high clinical pregnancy rate, implantation rate and live birth rate. And frozen-thawed blastocyst transfer is associated with high clinical pregnancy rate, implantation rate, live birth rate and multiple pregnancy rate, and abortion rate is reduced to some extent. Key words: Polycystic ovary syndrome; In vitro fertilization-embryo transfer; Whole embryos cryopreservation; Frozen-thawed embryo transfer; Clinical outcome