Efficacy of sublingual immunotherapy with Dermatophagoides farina drops in monosensitized and polysensitized children with allergic rhinitis and asthma

Abstract

Objective:To evaluate the efficacy of SLIT with Dermatophagoides farina drops in monosensitized and polysensitized children with allergic rhinitis and asthma.Method:This retrospective analysis chose 124 cases of allergic rhinitis and asthma with 3 years SLIT treatment. According to skin prick test,they were divided into two groups, monosensitized group (48 patients) and polysensitized group (76 patients). Before SLIT and after SLIT for 1 year, 2 year and 3 years, the TNSS, TRMS of rhinitis and DASS, NASS, TAMS, VAS, PEF, FEV1 of asthma were evaluated. Result:The TNSS, TRMS, DASS, NASS, TAMS, VAS, PEF, FEV1 had continuously improved significantly after SLIT for 1 year, 2 year and 3 years in two groups as compared with baseline (P< 0.05). As compared with after SLIT for 1 year, after SLIT for 2 year the TNSS, TRMS, TAMS, VAS of monosensitized group had obviously decrease (q= 3.76, 5.57, 6.02, 5.62, P< 0.05). As compared with after SLIT for 1 year, similarly, after SLIT for 2 year the TNSS, TRMS, TAMS, VAS of polysensitized group had obviously decrease (q= 5.40, 7.16, 7.19, 7.87, P< 0.05). Before SLIT, TRMS and TAMS of polysensitized group were significantly greater than the monosensitized group (Z=3.16, 2.74, P< 0.05). After SLIT for 1 year, 2 years and 3 years, the all evaluation indicators of two groups were not statistically significant (P> 0.05).Conclusion:Sublingual immunotherapy with Dermatophagoides farina drops in monosensitized and polysensitized children with allergic rhinitis and asthma had similar and significant therapeutic effect.