Efficacy of single dose versus multiple dose antibiotic prophylaxis in anterior abdominal wall hernia repair at a tertiary hospital

Abstract

Introduction: Our study is aimed to compare the impact of single vs. multiple dose of antibiotic in terms of post-operative infection related complications. In Anterior Abdominal Wall Hernia Repair at a Tertiary Hospital. Materials and Methods: The present study was prospective and longitudinal. Protocol of the procedure was formed along with Performa, Patient Information Sheet and Informed Consent Form. This study was carried out from October 2017 to September 2018 in surgery department of SSMC, Tumkur, in association with. Total 100 patients who were admitted for elective surgery were included in our study. The patients were randomly divided in two equal groups: single dose (SD) group and multiple dose (MD) group, comprising of 50 patients in each group. SD group was given Amoxycillin-Clavulanic acid (2 gm) intravenously at the time of induction of anaesthesia. Whereas, MD group was given Amoxycillin-Clavulanic acid (2 gm) intravenously at the time of induction of anaesthesia followed by Amoxycillin-Clavulanic acid (1 gm) intravenously twice a day for two days post-operatively. Results: In single dose antibiotic group, total post-operative infection rate was 8% and that in multiple dose groups was found to be 0%. Data was analyzed with Chi- square test and the difference in the rate of SSI in both the groups was found statistically insignificant. Conclusion: The rate of post-operative SSI after single dose antibiotic intravenously at induction of anaesthesia is comparable with that of multiple dose antibiotics. So single dose antibiotic regimen can be safely practiced in this surgery.