Abstract
INTRODUCTION :- Laparoscopic cholecystectomy is very commonly performed surgery for symptomatic cholelithiasis. There is very low risk of infective complications in elective Laparoscopic cholecystectomy and hence standard guideline doesn't recommend prophylactic antibiotic usage for low risk cases. However it is very commonly practicised in dosage and duration inconsistent among various surgeons. This study is being done to assess the efcacy of single dose antibiotic prophylaxis over multiple dose in the prevention of surgical site infection in patients undergoing elective laparoscopic cholecystectomy to avoid antibiotic resistance and overuse of it . METHODS: The study included 60 patients admitted for elective Laparoscopic cholecystectomy. First 30 patients received injectable ceftriaxone 1 gram intravenous peri-operatively, rst dose twelve hour before surgery and second dose half hour before surgical incision and then followed by injection (conventional dose) ceftriaxone 1 gram/day iv twice daily for the rst 5-7 days post-operatively. Next 30 was dened as the single dose (post-operative) antibiotic patients , this group were given only single dosage of injectable ceftriaxone 1 gram intravenous post-operatively.operation-room anesthetic assistant administered prophylactic antibiotics at induction of anaesthesia to all the patients. On the third, fth, tenth and fteenth days post operatively, based on Southampton scoring system the wound was seen and grading of the infection was done RESULT: The post-operative surgical site infection rate in group receiving single dose was 7.76 % and that in multiple dose group was found to be 6.67% . Chi- square test was used to analyse the data and the difference in the rate of SSI in both the groups was found to be statistically insignicant. CONCLUSION: There is no signicant difference in the outcome of elective laparoscopic cholecystectomy in terms of post operative surgical site infection in single dose and multiple dose group. Also single dose of antibiotics are more patient compliant, cost effective, have less adverse effects and reduce the incidence of antibiotic resistance
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