Efficacy of Shenqi Pollen Capsules for High-Altitude Deacclimatization Syndrome via Suppression of the Reoxygenation Injury and Inflammatory Response.

Binfeng He,Yongjun Luo,Zhenyu Liu,Guansong Wang,Zhiwei Dong,Liang Guo,Mingdong Hu,Zhihui Liang,Qianli Ma,Kexiong Lin,Qi Li,Yunhai Zi,Guisheng Qian

doi:10.1155/2019/4521231

Abstract

High-altitude deacclimatization syndrome (HADAS) is involved in hypoxia-reoxygenation injury and inflammatory response, induced a series of symptoms, and has emerged as a severe public health issue. Here, we investigated the mechanism as well as potential means to prevent HADAS using Shenqi pollen capsules (SPCs) in subjects with HADAS in a multicenter, double-blinded, randomized, placebo-controlled study. All subjects were at the same high altitude (3650 m) for 4-8 months before returning to lower altitudes. Subjects (n = 288) in 20 clusters were diagnosed with mild or moderate HADAS on the third day of the study. We randomly allocated 20 clusters of subjects (1 : 1) to receive SPCs or a placebo for 7 weeks, and they were then followed up to the 14th week. The primary endpoints were subjects' HADAS scores recorded during the 14 weeks of follow-up. Compared with the placebo, SPC treatment significantly decreased the subjects' HADAS scores and reduced the incidence of symptom persistence. SPC therapy also reduced the serum levels of CK, CK-MB, LDH, IL-17A, TNF-α, and miR-155 and elevated IL-10 and miR-21 levels. We thus demonstrate that SPCs effectively ameliorated HADAS symptoms in these subjects via suppression of the hypoxia-reoxygenation injury and inflammatory response.

Highlights

High-altitude deacclimatization syndrome (HADAS) is a serious form of high-altitude deacclimatization (HADA), in which the loss of high-altitude acclimatization provokes complex and multifaceted physiological and functional changes in individuals who have acclimated to a high altitude and returned to a lower altitude or sea level [1,2,3,4,5,6,7]
HADA occurs under typical environmental reacclimatization in which individuals return to lower altitudes from high altitudes
Similar to the process of high-altitude acclimatization (HAC), the physiological processes associated with the progression of HADA in a time-dependent manner: acclimatory changes and acquired hypoxia tolerance are not lost immediately upon returning to lower altitudes but instead disappear gradually over time

Summary

Introduction

High-altitude deacclimatization syndrome (HADAS) is a serious form of high-altitude deacclimatization (HADA), in which the loss of high-altitude acclimatization provokes complex and multifaceted physiological and functional changes in individuals who have acclimated to a high altitude and returned to a lower altitude or sea level [1,2,3,4,5,6,7]. HADA occurs under typical environmental reacclimatization in which individuals return to lower altitudes from high altitudes. Similar to the process of high-altitude acclimatization (HAC), the physiological processes associated with the progression of HADA in a time-dependent manner: acclimatory changes and acquired hypoxia tolerance are not lost immediately upon returning to lower altitudes but instead disappear gradually over time. HADA symptoms are similar to those of individuals who suffer from high-altitude stress. A previous study showed that migrants from high plateaus suffered from excessive somnolence, diminished reflexes, and inadequate

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