Abstract
High-altitude deacclimatization syndrome (HADAS) is emerging as a severe public health issue that threatens the quality of life of individuals who return to lower altitude from high altitude. In this study, we measured serum levels of SOD, MDA, IL-17A, IL-10, TNF-α, and HADAS score in HADAS subjects at baseline and 50th and 100th days and to evaluate the relationship between interleukins, including IL-17A, and HADAS. Our data showed that and the serum IL-17A levels and HADAS score decreased over time in the HADAS group, and serum IL-17A levels were significantly higher in the HADAS group at baseline and 50th day compared with controls (p < 0.05). Furthermore, baseline serum levels of MDA and TNF-α were significantly higher, while SOD and IL-10 levels were lower in HADAS subjects compared with controls (p < 0.05). It is interesting that serum levels of IL-17A were clearly interrelated with HADAS incidence and severity (p < 0.05). ROC curve analysis showed that combined serum IL-17A and IL-10 levels were a better predictor of HADAS incidence than serum levels of IL-17A or IL-10 alone. These data suggest that serum levels of IL-17A are a novel predictive index of HADAS.
Highlights
When people originally from a lower altitude descend to sea level or lower altitude after high-altitude/hypoxia acclimatization, they lose hypoxia tolerance and physiological adjustments
Serum levels of MDA and tumor necrosis factorα (TNF-α) were significantly higher and Superoxide dismutase (SOD) and Interleukin-10 TNF-α (IL-10) levels were lower in the high-altitude deacclimatization (HADA) syndrome (HADAS) group than in the control group at baseline
Serum levels of IL-17A, IL-10, and TNF-α were significantly correlated with HADAS score
Summary
When people originally from a lower altitude descend to sea level or lower altitude after high-altitude/hypoxia acclimatization, they lose hypoxia tolerance and physiological adjustments They experience changes in hemoglobin and hormone levels over time, and this is known as high-altitude deacclimatization (HADA) [1]. A previous study has shown that individuals suffering from HADA experienced symptoms such as sleepiness, insomnia, unresponsiveness, memory loss, fidgetiness, headache, throat pain or discomfort, coughing, sputum, chest tightness, becoming flustered, increased appetite, decreased appetite, diarrhea, abdominal distention, abdominal pain, lumbago, and arthralgia [6]. HADAS has been a public health issue in China and in other countries
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