Efficacy of piperzine citrate, stabilized with Aluminium-Magnesium Silicate, against &amp;lt;i&amp;gt;Helignosomoides bakeri&amp;lt;/i&amp;gt;

Maduike C O Ezeibe,Ihuoma E Ezeala,Chigozie D Dire,George N Anosa,Ogechukwu N Chikelu,Idika K Idika,Obianuju N Okoroafor,Augustine A Ngene,Temitope M Ogunniran,Okechi K Okorie

doi:10.4236/health.2012.410135

Abstract

To test effect of a synthetic Aluminium-Magnesium Silicate (AMS) on anthelmintic efficacy of piperazine citrate (PC), 35 mice were infected by dosing each, 0.15 ml Helignosomoides bakeri sample which contained 200 infective larvae, per os. Following comfirmation of establishment of infection by faecal floatation, they were assigned into seven groups of 5 each, and were treated with piperazine citrate, per os, at rates of 110 mg/kg (PC), 110 mg/kg (PC in AMS), 82.5 mg/kg (PC), 82.5 mg/kg (PC in AMS), 55 mg/kg (PC) and 55 mg/kg (PC in AMS) respectively. The seventh group served as untreated control. Mean Eggs Per Gramm of faeces (EPG) were 375 ± 32.27, 175 ± 14.43, 830 ± 1.04, 70 ± 12.25, 850 ± 293.06, 370 ± 58.54 and 2,200 ± 2.55 respectively. This showed EPG reduction rates of 83%, 92%, 62%, 97%, 61% and 83% among the respective treated groups.

Highlights

Helminthosis is one of the world’s most important parasitoses
There are increasing reports of development of resistance by helminth parasites against piperazine and other anthelmintics [2,3,4]. This calls for research for drugs to combine with piperazine salts for treatment of helminthosis, to improve their efficacy, for better perfomance of livestock and to reduce rate of development of anthelmintic resistance
Ability of the synthetic Aluminium-Magnesium Silicate (AMS) to enhance anthelmintic efficacy of piperazine citrate was tested against Helignosomoides bakeri

Summary

INTRODUCTION

Helminthosis is one of the world’s most important parasitoses. It is of both public health and economic importance [1]. There are increasing reports of development of resistance by helminth parasites against piperazine and other anthelmintics [2,3,4] This calls for research for drugs to combine with piperazine salts for treatment of helminthosis, to improve their efficacy, for better perfomance of livestock and to reduce rate of development of anthelmintic resistance. By stabilizing drugs’ active ingredients, AMS protects them from destruction It may protect piperazine citrate from being rapidly degraded by metabolic processes. If AMS is used at higher doses than presently used, these impurities may lead to adverse reactions To overcome this problem, Aluminium Silicate and Magnesium Silicate which are safe for use in pharmaceutical formulations [9] were reacted to get a synthetic AMS [11]. Ability of the synthetic AMS to enhance anthelmintic efficacy of piperazine citrate was tested against Helignosomoides bakeri

MATERIALS AND METHODS

RESULTS

DISCUSION