Efficacy of noninvasive positive pressure ventilation in patients with chronic obstructive pulmonary disease complicated with pulmonary hypertension

Abstract

Objective To investigate the therapeutic effect of noninvasive positive pressure ventilation on chronic obstructive pulmonary disease (COPD) complicated with pulmonary hypertension (PH). Method Patients admitted to hospital from October 2014 to January 2016 were treated with stable COPD and pulmonary hypertension, and sPAP was measured by echocardiography in all patients (>40 mmHg). 136 patients, including 121 males and 15 females, with an average age of (60.3±11.3)years, were randomly divided into noninvasive positive pressure ventilation (NPPV) group and conventional treatment group. The FEV1/predictive value, oxygenation index, PCO2, sPAP, BNP were compared between the two groups before and after treatment, and the correlation between sPAP and the oxygenation index, PCO2, BNP and FEV1/predictive value were analyzed. Result ①There was significantly improved between the NPPV group after treatment and NPPV group before treatment and the conventional group after treatment in the oxygenation index, PCO2, BNP (P 0.05). There was no significant difference between the two groups before and after treatment in conventional group (P>0.05); ②According to the values of sPAP were divided into A group (40 mmHg 60 mmHg). Stratified study showed that the FEV1/predictive value, BNP, sPAP were not significantly different before and after treatment between the group A and group B in the conventional group (P>0.05). The oxygenation index, PCO2, BNP, sPAP in NPPV after treatment of group A were improved between the NPPV before treatment and the conventional after treatment in group A (P 0.05); ③sPAP was negatively correlated with oxygenation index and positively correlated with BNP (P<0.05). Conclusion Noninvasive positive pressure ventilation is safe and effective in the treatment of elderly patients with chronic obstructive pulmonary disease and mild pulmonary hypertension. Key words: Noninvasive positive pressure ventilation; Chronic obstructive pulmonary disease; Pulmonary hypertension; sPAP