Efficacy of Mitomycin C for the treatment of serious reactions after dacryocystorhinostomy

Abstract

Objective To evaluate the efficacy of Mitomycin C for the treatment of serious reactions after dacryocystorhinostomy. Methods The data of 120 eyes of 120 patients with serious reactions after dacryocystorhinostomy were reviewed by endoscopy. They were randomly divided into two groups. In the control group, 60 paitent’s lacrimal duct were flushed with normal saline. In the test group, 60 paitent were appressed in anastomotic stoma with 0.2g/L Mitomycin C and last for 5 minutes before lacrimal ducts were flushed. Average follow-up time was (14.0±2.6) months. The degree of lacrimal duct patency and the complications were observed. Results There were 21 cases with serious obstruction and 26 cases with mild or moderate obstructive. And inflammation subsided for (3.5±0.6) months in control group. Serious obstruction occurred in 3 cases and mild or moderate obstructive in 22 cases. And inflammation subsided for (2.8±0.5) months in test group. The difference in the time of inflammation subsided was significant. Conclusion It is safe and effective for paitents with serious reactions using Mitomycin C after dacryocystorhinostomy. It can significantly inhibite the proliferation of adhesions occurrence, reduce inflammatory reactions, and rebuild a significant effect on the promotion of the lacrimal function. Key words: Dacryocystorhinostomy; Postoperaitive reaction; Mitomycin C; Efficacy