Efficacy of lymphotropic parenteral antibacterial therapy in patients with an acute pancreatitis

Abstract

Objective.To compare clinical results of application of lymphotropic antibacterial therapy (LATH) versus standard method of parenteral administration of antibiotics in patients, suffering an acute pancreatitis.
 Materials and methods. Clinical data, the values of the leucocyte and hematological intoxication indices, and some other indices of immunity, occurring on background of lymphotropic and standard antibacterial therapy, were studied. The patients were distributed into two groups: Group I (the main) - to whom lymphotropic antibioticotherapy was conducted, and Group II (a control one) - to whom a standard antibioticotherapy was applied.
 Results. In patients of the main group the pain syndrome, belching and regurgitation have had regressed during 2 days of treatment. During 5 days of treatment the intoxication signs have been eliminated. In the patients, admitted to hospital in the first day of an acute pancreatitis manifestation, the values of the intoxication leucocytes index after 5 days of the LATH conduction were on the level of corresponding index of practically healthy people, the CD3 and CD4 quantity raised statistically significantly, and the dimensions of the inflammatory changed pancreatic gland reduced.
 Conclusion. Lymphotropic injection of antibiotics and anti-inflammatory medicines promotes inhibition of inflammatory process in pancreatic gland. On background of adverse development of inflammation, a more rapid improvement of clinical symptoms of an acute pancreatitis, as well as in the indices of the common markers of inflammatory process and cellular immune defense, are observed. The data obtained witness the advantage of LATH over a standard (parenteral) one in the treatment of an acute pancreatitis.