Abstract
BackgroundThe oral systemic efficacy of lotilaner (Credelio™, Elanco) was evaluated against Demodex spp. in naturally infested dogs with generalized demodicosis.MethodsIn this study, 10 dogs with clinical signs of generalized demodicosis and positive for Demodex spp. mites based on skin scrapings were assigned to a single group orally treated with lotilaner (minimum dose of 20 mg/kg) on Days 0, 28 and 56.ResultsFor lotilaner-treated dogs, pre-treatment mite counts based on skin scrapings performed at five different sites were reduced by > 99.9% (P < 0.0001) up to 56 days after the first and second monthly doses. No live mites were detected after Day 56 out to and including Day 84 post-treatment for 100% efficacy of each dog’s Demodex mite infestation. Nine of 10 dogs were 100% mite-free from Day 28 (first evaluation) through Day 84 (end of study) and live mites were only found once on one dog (Day 56) following treatment with lotilaner. All dogs in the lotilaner-treated group showed marked improvement in the clinical signs of demodicosis and there were no drug associated adverse events. A marked improvement in hair re-growth was observed in all the dogs from 6 weeks following initiation of treatment.ConclusionsIn this study lotilaner administered at a minimum oral dose of 20 mg/kg was highly effective in reducing and eliminating live mite counts in dogs with natural infestations of Demodex spp.
Highlights
The oral systemic efficacy of lotilaner (CredelioTM, Elanco) was evaluated against Demodex spp. in naturally infested dogs with generalized demodicosis
No statistical testing was possible on Days 70 and 84 since skin scrapings were performed on only one dog at these time points
A single oral dose at a minimum of 20 mg/kg resulted in 100% reduction in Demodex mite counts at 28 and 42 days based on skin scrapings and ≥ 99.9% at the day 56 skin scrapings performed just prior to the third and final dose
Summary
The oral systemic efficacy of lotilaner (CredelioTM, Elanco) was evaluated against Demodex spp. in naturally infested dogs with generalized demodicosis. Canine demodicosis is a parasitic skin disease characterized by an excessive increase of Demodex spp. mites within the pilosebaceous glands [1]. Canine demodicosis is classified as localized or generalized according to the extent of the disease. Localized demodicosis is a Chronic generalized demodicosis is a frustrating and difficult skin disease to treat [4, 5]. Snyder et al Parasites & Vectors (2017) 10:532 long term chronic generalized demodicosis, the disease is unlikely to resolve without therapy [3]. Available therapeutic options involve daily, weekly, biweekly or monthly treatments for periods of 3 months or more [1, 5, 6]
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