Abstract
IntroductionGonadotropin-releasing hormone analogs (GnRHa) are the treatment of choice for CPP. We investigated growth in GnRHa-naïve subjects, treated with leuprolide acetate 1-month depot for CPP.MethodsThis prospective, open-label study had a long-term, observational, follow-up period. Forty-nine females and 6 males were enrolled. Leuprolide acetate depot was administered intramuscularly every 28 days. Height and growth rate during and after treatment until adulthood were measured.ResultsAmong 30 of 49 females having an adult height (AH) measurement, 29 had target heights available (mean = 163.8 cm) and 27 had pretreatment predicted adult heights (PAHs; mean = 157.4 cm). After treatment, the mean AH at mean age 21.8 years [range 13.7-26.7 years] was 162.5 cm, a mean height gain over baseline PAH of 4.0 cm. The mean height standard deviation score was -0.1 at AH.ConclusionsTreatment of CPP with leuprolide acetate 1-month depot had beneficial effects on growth rate and preservation of AH.Trial RegistrationClinicalTrials.gov: NCT00660010
Highlights
Gonadotropin-releasing hormone analogs (GnRHa) are the treatment of choice for Central precocious puberty (CPP)
We describe the auxological outcomes of the study and analyze the effect of multiple baseline and during-treatment factors that potentially affect height outcomes in females
All patients were naïve to treatment with GnRHa
Summary
Gonadotropin-releasing hormone analogs (GnRHa) are the treatment of choice for CPP. We investigated growth in GnRHa-naïve subjects, treated with leuprolide acetate 1-month depot for CPP. The few previous studies that have examined outcomes during and after treatment with leuprolide acetate have utilized variable treatment doses, and generally small numbers of patients [14,15,16]. The objectives of this longitudinal, prospective study were to evaluate the suppression of hormonal and clinical sexual characteristics and to examine the long-term impact of baseline and during-treatment factors on the growth pattern and adult height after treatment with leuprolide acetate 1month depot in females with CPP. A separate article reports the hormonal and reproductive outcomes of the study [17]
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