Efficacy of infliximab in neuro-Behçet’s disease presenting with isolated longitudinally extensive transverse myelitis

Ryo Kuroda,Masahiro Kobari,Asami Tasaki,Junko Suzuki,Mariko Yano,Noboru Imai,Mizuho Muramatsu,Masahiro Serizawa

doi:10.1007/s00415-013-7150-5

Ryo Kuroda, Masahiro Kobari + Show 6 more

Open Access

https://doi.org/10.1007/s00415-013-7150-5

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Abstract

Efficacy of infliximab in neuro-Behçet’s disease presenting with isolated longitudinally extensive transverse myelitis

Highlights

Behcet’s disease (BD) is a relapsing systemic inflammatory disorder of unknown etiology, showing common characteristics of oral and genital ulcers and uveitis
Use of tumor necrosis factor (TNF)-alpha antagonist therapy has been described for neuro-Behcet’s disease (NBD) [6,7,8]
Reports of NBD with spinal cord involvement describing the efficacy of anti-TNF-alpha therapy are scarce [9]

Summary

Introduction

Behcet’s disease (BD) is a relapsing systemic inflammatory disorder of unknown etiology, showing common characteristics of oral and genital ulcers and uveitis. In NBD, the frequency of spinal cord involvement is 8–14 % [4, 5]. Use of tumor necrosis factor (TNF)-alpha antagonist therapy has been described for NBD [6,7,8]. Reports of NBD with spinal cord involvement describing the efficacy of anti-TNF-alpha therapy are scarce [9].

Results

Conclusion