Abstract
Purpose : To study the efficacy of glucocorticoid combined with hyperbaric oxygen therapy for the treatment of delayed encephalopathy after carbon monoxide poisoning (DEACMP), and its effect on the expression of immune-associated cytokines. Methods : A total of 102 DEACMP patients in PLA General Hospital, Haidian, China were divided into two groups of 51 patients each, namely, observation group (glucocorticoid + hyperbaric oxygen therapy), and control group (hyperbaric oxygen only). The clinical data for each group was retrospectively analyzed. Clinical efficacy, improvement time, hospitalization time, cognitive function, activities associated with daily living, changes in immunity-associated cytokines, and incidence of adverse reactions were compared for the two groups. Results : Following treatment, the time taken for improvement, duration of hospitalization, cognitive function, daily living activity and total effectiveness in the observation group were significantly higher than those for the control group (p 0.05). Conclusion : These results suggest that a combination therapy of glucocorticoid and hyperbaric oxygen therapy for the treatment of DEACMP is more eutherapeutic in the improvement of cognitive function and activities of daily living in DEACMP patients than hyperbaric oxygen therapy. The mechanism of this combination therapy may be related to the improvement in immunity-related cytokine levels. Keywords : Glucocorticoid, Hyperbaric oxygen, Delayed encephalopathy after carbon monoxide poisoning, Efficacy, Immunity
Highlights
In acute carbon monoxide poisoning (ACMP), the binding of carbon monoxide to hemoglobin produces toxins in histiocytes of the whole body, resulting in the loss of oxygen carrying capacity and asphyxia of body tissues [1,2]. the toxicity symptoms in some patients may be gradually reduced after rescue, thisIt has been reported that glucocorticoid combined with hyperbaric oxygen therapy is clinically eutherapeutic, and that the good brainprotective effect of glucocorticoid can effectively reduce the incidence of delayed encephalopathy after carbon monoxide poisoning (DEACMP) [6,7]
It has been reported that glucocorticoid combined with hyperbaric oxygen therapy is clinically eutherapeutic, and that the good brainprotective effect of glucocorticoid can effectively reduce the incidence of DEACMP [6,7]
The levels of transforming growth factor-β1 (TGF-β1), After treatment, the time taken before improvement, and hospitalization time in the observation group were shorter than those in the control group, and the total effectiveness was significantly higher in the observation group than in the control group (p
Summary
It has been reported that glucocorticoid combined with hyperbaric oxygen therapy is clinically eutherapeutic, and that the good brainprotective effect of glucocorticoid can effectively reduce the incidence of DEACMP [6,7]. The clinical data of 102 DEACMP patients in PLA General Hospital, Haidian were retrospectively analyzed, and the efficacy of combined glucocorticoid and hyperbaric oxygen therapy, as well as its effects on immune-associated cytokines were investigated. This was with a view to providing a theoretical bases for clinical treatment of DEACMP
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