Abstract
Introduction: Benzydamine hydrochloride is an NSAID most often used in radiation induced oral mucositis. The indazole analogue benzydamine has physical,chemical, and pharmacological properties which differ from those of the aspirin-like NSAIDs. Benzydamine specifically act on the local mechanisms of inflammation, granuloma, and exudate.
 Methodology: The study was a double-blinded, randomized, controlled clinical trial. A total of 30 chronic periodontitis patients reported to the dental hospital were selected for the study using a purposive sampling technique. Thirty chronic periodontitis patients scheduled for periodontal surgeries were randomized to receive either Benzydamine hydrochloride Mouthwash (MW) or Diclofenac Tablets (TB), post-surgery. The MW group patients were advised to rinse with undiluted 15 ml solution for 60 secs, 2-5 times daily for three days. TB group were asked to take 50 mg tablet twice daily for three days. A 10-point Visual Analog Scale (VAS) and Wong-Baker Facial Rating Scale (FRS) were recorded to measure the pain perception by the patients.Gingival status was assessed by the Modified Gingival Index (MGI) at baseline and seventh day.
 Results: Intra-group comparison of pain values at day 1 and day 2 in both VAS and WONGBAKER scales demonstrated significance for the mouthwash group, suggesting more efficacy than the tablet group. Inter-group results showed statistical significance in both groups in relief of pain (p<0.05). Intra-group comparison results for both groups signified the superior efficacy of the mouthwash with p-values 0.010 and 0.005 at day 1 and day 2 for the Wong-Baker scale and with p-values 0.020 and 0.017 for VAS scale.
 Conclusion: Inter-group comparison at baseline, day 1, day 2 showed significant results on day 1 and day 2, suggesting both the products were effective. Intra-group comparison of pain values in both VAS and WONG BAKER scales showed the significance of the mouthwash group, suggesting more efficacy than the tablet.
 Keywords: Pain, Benzydamine hydrochloride mouthwash, Post-periodontal surgery.
Highlights
Benzydamine hydrochloride is an nonsteroidal antiinflammatory drugs (NSAIDs) most often used in radiation induced oral mucositis
Benzydamine hydrochloride NSAID mouthwash was used as an analgesic, which acts locally and has higher absorbability due to the lipid-soluble nature of the drug
In this study, Benzydamine mouthwash was assessed for post periodontal surgery pain relief and evaluated if it would be a better alternative to the systemic administration of the Diclofenac tablet
Summary
Benzydamine hydrochloride is an NSAID most often used in radiation induced oral mucositis. Results: Intra-group comparison of pain values at day 1 and day 2 in both VAS and WONGBAKER scales demonstrated significance for the mouthwash group, suggesting more efficacy than the tablet group. Intra-group comparison of pain values in both VAS and WONG BAKER scales showed the significance of the mouthwash group, suggesting more efficacy than the tablet. Benzydamine hydrochloride NSAID mouthwash was used as an analgesic, which acts locally and has higher absorbability due to the lipid-soluble nature of the drug. It can by-pass the complications related to the systemic administration of the drugs
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