Abstract
OBJECTIVES:To evaluate the efficacy of autologous platelet-rich plasma (PRP) gel in the treatment of refractory pressure injuries and its effect on wound healing time and quality of life of patients.METHODS:A random number table method was used to group 102 patients with refractory pressure injuries into either a control group (CG) (51 cases) receiving negative pressure wound therapy (NPWT) or a study group (SG) (51 cases) receiving NPWT+PRP gel.RESULTS:The total efficacy rate in the SG (92.16%) was higher than that in the CG (76.47%) (p<0.05). The SG exhibited lower visual analog scale (VAS) scores and pressure ulcer scale for healing (PUSH) scores, smaller wound sizes and depths, and shorter wound healing times than the CG after 21 days of treatment (p<0.05). After 6 months of treatment, the SG scored higher than the CG on the psychological, physiological, social functions, and daily activity domains on the World Health Organization Quality of Life (WHOQOL-BREF) scale (p<0.05). The incidence of postoperative complications in the SG (13.73%) was not significantly different from that of the CG (7.84%) (p>0.05).CONCLUSION:In the treatment of refractory pressure injuries, PRP gel can accelerate wound healing, reduce wound pain, shorten the treatment cycle, regulate tissue inhibitor matrix metalloproteinase-1 (TIMP-1) and matrix metalloproteinase-9 (MMP-9) levels and the expression of specific proteins in granulation tissue, reduce the levels of the inflammatory factors interleukin-1β (IL-1β), IL-8, and tumor necrosis factor-α (TNF-α), and improve the quality of life of patients without increasing complications.
Highlights
Pressure injuries are localized damage to the skin and/or underlying tissue induced either by pressure alone or by a pressure-shear combination
Pressure injuries are associated with local tissue necrosis due to hypoxia/ischemia resulting from long-term compression [1,2]
Comparison of wound healing-related indices Before treatment, visual analog scale (VAS) scores, pressure ulcer scale for healing (PUSH) scores, and wound healing times did not differ between the two groups (p40.05)
Summary
Pressure injuries are localized damage to the skin and/or underlying tissue induced either by pressure alone or by a pressure-shear combination. These injuries often occur in patients on long-term bed rest, those with difficulty moving their lower extremities, and in patients with altered consciousness. Pressure injuries are associated with local tissue necrosis due to hypoxia/ischemia resulting from long-term compression [1,2]. Refractory pressure injuries are mostly found in stage III and IV wounds. Stage III and IV pressure injuries are characterized by full-thickness tissue loss.
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