Efficacy of Atorvastatin in Prevention of Contrast induced Nephropathy in Patients Undergoing Coronary Angiography

Abstract

Abstract Background The use of radiocontrast media has increased greatly from the past decades for diagnostic radiography and interventional procedures and it is estimated that approximately 60 million people in the world are used radiocontrast media each year. Objective The aim of this study was to evaluate the efficacy of atorvastatin (ATN) 80 mg in the prevention of CIN in patients undergoing angiography. Patients and Methods This study was a prospective, two‑arm, parallel group, controlled, clinical trial. This study has been performed on 100 Egyptian patients. Patients of either sex and aged between 21 and 65 years admitted for coronary angiography from January 2019 to June 2019, the patients had serum cretinine between 1 and 1.5 mg/dl or estimated glomerular filtration rate (eGFR > 60 ml/min/1.73m2) and suffering from controlled DM or HTN. Results As regard to prevalence of contrast nephropathy, in our study we found that the total prevalence was 13%. We have concluded a great effect of diabetes on development of contrast nephropathy. We have concluded a great effect of hypertension on development of contrast nephropathy. There was a great effect of number of vessels affected on development of contrast nephropathy. As regard FBS there was no significant difference between the two groups. Also, there was a highly significant positive correlation between and study markers of acute kidney injury (72 h- Serum creat Delta Serum creat, 72 h- GFR and Delta GFR) and FBS. As regard Contrast media dose there was no significant difference between the two groups. Also, there was a highly significant positive correlation between and study markers of acute kidney injury (72 h- Serum creat Delta Serum creat, 72 h- GFR and Delta GFR) and contrast media dose. In our study there was a highly significant difference between the two groups as regard study markers of evidence of contrast nephropathy (72 h- Serum creat Delta Serum creat, 72 h- GFR and Delta GFR).Also, there was a great effect of on development of contrast nephropathy. In our study there was a highly significant difference between the two groups as regard study markers of evidence of contrast nephropathy (72 h- Serum creat Delta Serum creat, 72 h- GFR and Delta GFR).Also, there was a great effect of on development of contrast nephropathy. Conclusion There was a beneficial significant effect of statin on prevention of contrast nephropathy, also we concluded that age, hypertension, DM, dyslipidaemia, FBS, hemoglobin level, serum uric acid and dose of contrast media are major risk factors for developing contrast nephropathy.