Efficacy of 2-week standard quadruple therapy and sequential treatment for post-endoscopic submucosal dissection ulcer with Helicobacter pylori infection

Abstract

Objective To evaluate the therapeutic efficacy of a 2-week standard quadruple therapy and sequential treatment for post endoscopic submucosal dissection(ESD) ulcer with Helicobacter pylori(H.pylori) infection. Methods Sixty patients with H. pylori infection who underwent gastric ESD were divided into the H. pylori eradication group (n=30) and the control group (n=30) according to the random number table. The ulcer diameter and the ulcer healing rates at 4-wk and 8-wk and 12-wk were monitored and compared between the two groups. Results The ulcer diameter and area at 4-wk and 8-wk in the H. pylori eradication group were lower than those of the control group, but the scarring rate of ulcers of S1 was higher than that of the control group with no significant difference. All the ulcers were scarring healing in the H. pylori eradication group at 12-wk, but 5 cases failed in the control group. The ulcer diameter(2.0±4.3)mm and area(21±48)mm2 in the control group were significantly higher than those in the H. pylori eradication group at 12-wk. And the healing rate of ulcers in the H. pylori eradication group was significantly higher than that in the control group at 12-wk (P<0.05). The level and quality of the ulcer healing in the H. pylori eradication group were significantly higher than those in the control group (P<0.05). Conclusion The 2-week standard quadruple therapy for H. pylori eradication could improve the level and quality of ulcer healing of the ESD-induced ulcers, and enhance the healing rate of ulcers in patients with H. pylori infection. Key words: Ulcer; Helicobacter pylori; Treatment outcome; Endoscopic submucosal dissection