Abstract
The varicella-zoster is a dangerous virus that has the potential to lead to many fatal conditions. People with low immune systems tend to be affected by this virus and they are more prone to HZ and its complications. This virus can't be treated with an antiviral drug as they may not respond to them. It's important to note that the live attenuated vaccine and the adjuvant recombinant subunit vaccine have different characteristics and recommended uses for individuals with compromised immune systems. This paper aims to assess these vaccines' efficacy, effectiveness, and safety in such individuals. However, autoimmune therapy may create more side effects which can be more in the injection use. In conclusion, vaccination is a measure against HZ and its complications for people with compromised immune systems. The RZV vaccine is widely regarded as the choice because it has shown effectiveness and is considered safe, for different groups of people, with weakened immune systems. For people, with slight immune-compromised, the ZVL vaccine might be a choice. However, it's crucial to assess each situation on a basis.
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