Abstract
Abstract Background/Aims: In daily feminine hygiene in women prone to genital dryness, it is rational to use a specific detergent (SH) containing less aggressive natural surfactants which stimulate epidermal renewal of keratinocytes, agents increasing bioadhesiveness of hydrating components; and plant extracts with natural antimicrobial, and antiinflammatory activity. This study evaluated efficacy and acceptability of SH (Saugella Hydraserum) compared with a standard detergent (C) in women with vaginal dryness. Methods: Women of childbearing potential with vaginal dryness were randomised to treatment with SH or with C, b.i.d. for 4 weeks in a controlled, balanced, parallel-group study stratified by clinical condition. Clinical evaluations were performed at baseline and every week. Results: A total of 120 women were treated, 60 per treatment, mean age 32.6 years, with dryness due to hormone deficiency or hypersensitive to normal detergents. Symptoms severity was significantly reduced in favour of SH for pruritus (67.4% ± 7.4 vs -36.8% ± 7.5, p<0.01), burning (-65.3% ± 7.4 vs -36.9% ± 7.2, p<0.05), erythema (-80.3% ± 6.6 vs -39.2% ± 9.8, p<0.05), dryness (-52.9% ± 7.1vs -16.2% ± 5.0, p<0.001), dyspareunia (-44.9% ± 6.2 vs -16.7% ± 6.6, p<0.05). Conclusions: Saugella Hydraserum showed better clinical efficacy than normal intimate detergent on pruritus, burning, erythema, dryness, and dyspareunia in women with vulvovaginal dryness. This outcome was obtained by the combination of natural surfactants, offering skin protection, and a complex of active substances, aimed both at normal hydration of the external genitalia and prevention of microbial contamination.
Highlights
IntroductionA possible solution to the problem of feminine hygiene for these categories of women may be a specific latest-generation detergent (SH) whose formulation is non-irritant due to the fact that it contains surfactants of natural origin (derivatives of coconut and amino acids of wheat), which ensure gentle cleansing with prolonged hydration
The use of products for feminine hygiene aimed at the specific pathophysiological condition is able to improve feminine hygiene in a clear and noticeable manner
The frequency of cases with disappearance of the symptom/sign was significantly greater for the SH group versus controls (p
Summary
A possible solution to the problem of feminine hygiene for these categories of women may be a specific latest-generation detergent (SH) whose formulation is non-irritant due to the fact that it contains surfactants of natural origin (derivatives of coconut and amino acids of wheat), which ensure gentle cleansing with prolonged hydration. These surfactants stimulate epidermal renewal of keratinocytes and are able to restructure damaged skin and restore the lipid layer of the skin that is removed during normal routine washing.
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