Abstract
Background:This study was designed to systematically evaluate the clinical efficacy and safety of ultrasound-guided intrathyroidal injection of glucocorticoids (GCs) versus routine oral administration of GCs for subacute thyroiditis (SAT) and to help seek evidence of evidence-based medicine (EBM) for ultrasound-guided intrathyroidal injection of GCs in the treatment of SAT.Methods:Seven Chinese and English databases, including Chinese National Knowledge Infrastructure, Wanfang Data, VIP Information China Science and Technology Journal Database, SinoMed, PubMed, Cochrane Library, and Embase, were searched to collect randomized control trials on ultrasound-guided intrathyroidal injection of GCs in the treatment of SAT, which were published up to July 1, 2019. According to the method as described in Cochrane Reviewers’ Handbook 5.1.0, the Cochrane Collaboration's tool for assessing risk of bias was employed to evaluate the quality of the literatures included. Statistical analysis was made by using Stata 12.0. The “metanif” command was used for sensitivity analysis to assess the stability of the results. Funnel diagram method, Egger linear regression method, and clipping complement method were used to evaluate publication bias.Results:This study was carried out in strict accordance with the standard procedures for meta-analysis in the Cochrane Reviewers’ Handbook 5.1.0. Critical data about the primary and secondary outcome measures were obtained by statistical analysis.Conclusion:This study would draw a definite conclusion about whether ultrasound-guided intrathyroidal injection of GCs is effective and safe in the treatment of SAT on the basis of EBM. This conclusion would provide scientific evidence for the clinical treatment of SAT.
Highlights
Subacute thyroiditis (SAT) is the most common painful thyroid disease
The results of this study would be published in a high-quality international academic SCI journals
It is generally accepted in Western medicine that subacute thyroiditis (SAT) is linked to viral infection and allergic reaction
Summary
Subacute thyroiditis (SAT) is the most common painful thyroid disease. Some study has shown that viral infection may lead to the destruction of thyroid follicular cells and the colloid released will cause foreign body reaction in the thyroid tissue and fibrosis.[4] Some study finds that the occurrence of SAT is associated with genetic factors.[5] The course of SAT often lasts for 2 to 3 months, and typical SAT may be divided into 3 stages according to the clinical characteristics. SAT causes severe pain, thyroid follicular cells are damaged, and thyroid hormones are released into blood, which may result in transient hyperthyroidism; at the remission stage transient hypothyroidism will occur; at the recovery stage, the thyroid function may recover to normal, but individual patients will suffer from permanent hypothyroidism. This study was designed to systematically evaluate the clinical efficacy and safety of ultrasound-guided intrathyroidal injection of glucocorticoids (GCs) versus routine oral administration of GCs for subacute thyroiditis (SAT) and to help seek evidence of evidence-based medicine (EBM) for ultrasound-guided intrathyroidal injection of GCs in the treatment of SAT
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
