Abstract
Objective To investigate the efficacy and safety of pidotimod combined with budesonide aerosol in the treatment of bronchial asthma in children. Methods Selected 200 cases children with asthma treated in hospital outpatient from June 2011 to September 2012 as research subjects. They were randomly divided into observation group (n = 100,budesonide aerosol + pidotimod) and control group (n = 100, budesonide aerosol) according to the different therapeutic methods. Comparison of the two groups of gender, average age,duration and severity grading and other basic information on aspects of children, the differences were not statistically significant (P>0. 05). In this study, the procedure followed in line with ethical standards established by Institutional Review Board of the Central Hospital of Mianyang, approved by the Commission, grouping the consent of the guardian of the children tested, and with the signing of informed consent in clinical research. The following information were compared between two groups,the number of asthma attacks,attack duration and extent of attack. Results The efficient of observation group was significantly higher than that in control group(95. 00% vs. 74. 00%,P<0. 01). The number of asthma attacks, attack duration [(4. 00±1. 32) d vs. (6. 78 ± 1. 58) d,P<0. 05] and extent of attack(P<0. 01) were significantly shorter than those of control group. Conclusions Pidotimod combined with budesonide aerosol in the treatment of bronchial asthma in children is better than budesonide only. Key words: asthma; pidotimod; budesonide; treatment outcome; child
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