Abstract

Chronic pelvic pain syndrome (CPPS) is one of the most common outpatient urological diagnoses, and its incidence is increasing. Extracorporeal shockwave therapy (ESWT) has been suggested for relieving local perineal symptoms associated with chronic prostatitis/CPPS. Despite several treatment methods, no causal or standardized treatment is available for CPPS. This study aimed to investigate the efficacy and safety profile of ESWT for the treatment of chronic non-bacterial prostatitis. Studies were collected using four search engines (Pubmed, Cochrane, ScienceDirect, and EBSCOHost), on May 16, 2020; and assessed based on predetermined inclusion and exclusion criteria. Two reviewers performed study selection. Studies were then analyzed using Review Manager 5.3 for the meta-analysis. Seventy-four publications were initially retrieved, and three studies were considered for both qualitative and quantitative analyses. From these studies, we found that the use of ESWT was significantly associated with decreased pain domain (mean difference: -3.93; 95% confidence interval [CI] -5.13, -2.73; p<0.001), improved urinary score (mean difference: -1.79; 95% CI -2.38, -1.21; p<0.001), improved quality of life (mean difference: -1.71; 95% CI -2.12, -1.31; p<0.001), and improved National Institutes of Health chronic prostatitis symptom index (NIH-CPSI) score (mean difference: -5.45; 95% CI -5.74, -5.16; p<0.001) after 12 weeks of treatment. ESWT is efficacious and safe in reducing pain and improving urinary condition, NIH-CPSI score, and quality of life in patients with chronic non-bacterial prostatitis.

Highlights

  • Since the acceptance of the consensus of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/Chronic pelvic pain syndrome (CPPS)) in 1995 [1], reports of this urological condition have increased to date [1,2,3]

  • We found that the use of Extracorporeal shockwave therapy (ESWT) was significantly associated with decreased pain domain, improved urinary score, improved quality of life, and improved National Institutes of Health chronic prostatitis symptom index (NIHCPSI) score after 12 weeks of treatment

  • Since the acceptance of the consensus of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) in 1995 [1], reports of this urological condition have increased to date [1,2,3]

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Summary

Introduction

Since the acceptance of the consensus of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) in 1995 [1], reports of this urological condition have increased to date [1,2,3]. Symptoms of CPPS include urinary and erectile dysfunctions and pain in the prostate, perineal, inguinal, scrotal, and suprapubic regions, lasting for at least 3 of the previous six months [1]. CPPS affects patients’ quality of life (QOL) due to urinary and erectile dysfunctions [4]. QOL is associated with tremendous pain and urinary symptoms. The disease’s typical restrictions are pain sensations located in the prostate, testes, groin, back, pelvic floor, and suprapubic region [4]

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