Abstract
Objective: The most common strategy to improve blood pressure (BP) control is improving compliance with once daily administration of antihypertensive therapy. Aim: To assess the efficacy, tolerability, safety of different regimes of prescription of combination of perindopril 10 mg and indapamide 2.5 mg.Design and methods. We included 31 patients (56±9.3 years, BMI 30.5±5.3 kg/m2, duration of arterial hypertension - 7.1±5.8 years), on two-component therapy (except combination of perindopril and indapamide) with BP>140/90 mmHg. At baseline ambulatory blood pressure monitoring (ABPM), blood tests were performed in 20 men and 10 women, then, patients were randomized into two groups: morning and evening regimes. Previous therapy was canceled and prescribed a combination of perindopril 10 mg and indapamide 2.5 mg. After 8 weeks of treatment, ABPM and blood tests were re-conducted. Results. Baseline systolic blood pressure (SBP) and diastolic blood pressure (DBP) in the whole group - 148.4±10.0/95.6±10.7 mm Hg. After 1 and 2 months of treatment Noliprel-A bi-forte SBP/DBP decreased to 131.4±8.4/86.6±5.7 mm Hg and to 133.4±11.2/84.5±8.8 mm Hg respectively. ( p
Highlights
В настоящее время наиболее распространенная стратегия по улучшению контроля артериального давления (АД) – это улучшение приверженности к терапии, что достигается однократным приемом антигипертензивных препаратов
At baseline ambulatory blood pressure monitoring (ABPM), blood tests were performed in 20 men and 10 women, patients were randomized into two groups: morning and evening regimes
Tolerability was assessed by The combination of perindopril 10 mg and indapamide 2.5 mg effectively reduces BP by ABPM data
Summary
The most common strategy to improve blood pressure (BP) control is improving compliance with once daily administration of antihypertensive therapy. Aim: To assess the efficacy, tolerability, safety of different regimes of prescription of combination of perindopril 10 mg and indapamide 2.5 mg. We included 31 patients (56±9.3 years, BMI 30.5±5.3 kg/m2, duration of arterial hypertension – 7.1±5.8 years), on two-component therapy (except combination of perindopril and indapamide) with BP>140/90 mmHg. At baseline ambulatory blood pressure monitoring (ABPM), blood tests were performed in 20 men and 10 women, patients were randomized into two groups: morning and evening regimes. Tolerability was assessed by The combination of perindopril 10 mg and indapamide 2.5 mg effectively reduces BP by ABPM data. For citation: Elfimova E.M., Aksenova A.V., Litvin A.Yu., Chazova I.E. Efficacy and safety of different regimens of fixed combination of perindopril 10 mg/indapamide 2.5 mg in patients with arterial hypertension.
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