Efficacy and Safety of Desmopressin with Anticholinergics in Female Patients with Overactive Bladder

Abstract

ABSTRACT Aims and objectives The main aims and objectives of this study were to study efficacy, safety, and quality of life with combination anticholinergics and desmopressin compared to anticholinergics alone. Materials and methods A total of 92 patients were randomly assigned to two groups. Patients were randomly assigned to receive 5 mg of solifenacin (group I) or 5 mg of solifenacin and 0.2 mg of desmopressin (group II) for 1 month. The patients were followed for 2 weeks to look for undesired side effect and then at 1 month with 3-day voiding diary. IIQ-7 questionnaire score was used to assess changes in voiding symptoms and quality of life. Results Out of 42 in group I and 50 in group II, one patient in group I and three patients in group II did not follow and were excluded from the study. Baseline parameters between the two groups were statistically similar. Posttreatment parameters such as mean number of voids in first 8 hours decrease from 5.53 to 3.48 in group I vs 5.7 to 2.13 in group II, p valve <0.01. The mean number of urgency episodes in first 8 hours in group I decreased from 4.23 to 3.11 vs 4.68 to 2.29 in group II, p valve <0.01. The mean number of nocturnal voids in group I decreased from 3.55 to 2.48 vs 3.35 to 1.34 in group II, p valve <0.01. The mean IIQ-7 score in group I decreased from 51.10 to 32.8 vs 54.63 to 18.82 in group II, p valve <0.01. Differences were statistically significant. There was statistically insignificant change in serum sodium level posttreatment between group I and group II. Conclusion Combination of desmopressin and anticholinergics was more effective and safe than anticholinergics alone in the treatment of female patients with overactive bladder. Therefore, desmopressin combined with anticholinergics could be considered feasible and safe method for relief of symptoms in female patients with overactive bladder. However, larger and long-term studies for proper evaluation are warranted. How to cite this article Qureshi A, Malik SA, Ahmad MS. Efficacy and Safety of Desmopressin with Anticholinergics in Female Patients with Overactive Bladder. J South Asian Feder Obst Gynae 2020;12(3):178–181.