Efficacy analysis of IMRT on 22 cases with recurrent nasopharyngeal carcinoma

Abstract

Objective To analyze the efficacy of IMRT in the treatment of recurrentnasopharyngeal carcinoma. Methods Clinical data of 22 patients with recurrent nasopharyngeal carcinoma （NPC）were retrospectively analyzed,We have recurrent NPC tune the amount of synchronization push radiation therapy in patients with clinical data,treatment efficacy and acute toxicity were analyzed.Results All patients were hospitalized on average 50 days, between median follow-up period of 12 months.At the end of 22 patients with no treatment deaths,three deaths （both metastasis） during follow-up,overall survival 86.3%（19/22）,local recurrence in 2 cases,2 cases of bone metasta-sis,1 case of throat and neck lymph node metastasis.The local control rate was 63.6%（14/22）.Acute toxicity main-ly acute skin,oropharyngeal mucosa （12 cases） and bone marrow suppression （4 cases）.1 patient had symptoms of hearing loss and auditory nerve damage,1 case of necrosis of the mandible,all symptoms of dry mouth in patients with radiotherapy were heavier than that of the first drive.Conclusion With the growing popularity of IMRT,NPC patients had significantly improved overall survival, but distant metastasis and recurrence of the tumor, radiotherapy again cause adverse reactions in clinical practice still needs further development and improvement,IMRT treatoffing with re-current nasopharyngeal has broad prospects. Key words: Nasopharyngeal neoplasms/recurrence; Intensity modulated radiation therapy