Efficacies and influencing factors after Kasai operation for biliary atresia: a report of 99 cases

Abstract

Objective To explore the short/medium-term efficacies and influencing factors of biliary atresia (BA) after Kasai operation. Methods Retrospective analyses were performed for 99 children undergoing Kasai operation at Huaihe Hospital and Affiliated Hospital, Zhengzhou University. Follow-ups were conducted with complete data during August 2008 to July 2013. There were 54 females and 45 males with an average age of (3.33±1.26) (1-6) months. Their average operative age was (72.36±41.17) days and average follow-up period (30.03±9.80) months. The Kaplan-Meier survival analysis, Log rank and χ2 tests were used to analyze the clearance of jaundice, liver function recovery, BA classification, operative day age, presence/absence of cholangitis and survival rate. Results The recent rates of jaundice subsiding and liver function recovery of Ⅰ, Ⅱ, Ⅲ BA were 87.5%, 66.6%, 39.7% and 75.0%, 66.6%, 36.3% respectively. And the differences were statistically significant (P 120 days groups were 61.1%, 55.0%, 31.8%, 21.0% and 61.1%, 50.0%, 27.2%, 15.7% respectively. And the differences were statistically significant (P 0.05). The 5-year survival rates of three groups (liver function fair, worse and worst) were statistically significant (P<0.05). Conclusions Kasai operation remains a first choice for children with BA. And liver function recovery, operative age, type of BA and cholangitis are correlated with its outcomes. Key words: Biliary atresia; Cholangitis; Treatment outcome