Abstract
Summary The interferon response of non-sensitized human lymphocytes to 3 anti-rabies vaccines and to vesicular stomatitis virus (VSV) in vitro was studied using an assay of interferon-induced 2-5A-synthetase in lymphocyte extracts. Rabies vaccine prepared from foetal bovine kidney cells and a human diploid cell strain led to stimulation of enzymatic activity. The response to the two vaccines and to VSV showed a correlation in the lymphocytes of 72 % of subjects. In contrast, suckling mouse brain vaccine decreased the enzymatic activity, which was lower than the base level in lymphocytes of 67 % of subjects, probably due to an inhibitory substance in the brain from which this vaccine was prepared.
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