Abstract
Topical products for photoprotection are effective but for a short period of time and their efficacy is often limited by inadequate use. Systemic products have been developed to complement external methods of photoprotection. We assessed the effect of a combination of Porphyra umbilicalis, Polypodium leucotomos, and vitamins C and E on the minimal erythematous dose (MED). This was an open study with intra-individual comparisons performed in phototype II and III healthy volunteers who received the combination for 14 days. The MED was assessed at D0, D3, D7, and D14. At D14, a statistically significant MED increase of 19% (P < 0.001) was observed in 82% (18/22) of the volunteers. This MED increase was significant from D7 (+10%; P = 0.002). The analysis per phototype showed that the MED increase was significant from D3 in phototype II volunteers (N = 13; +7%; P = 0.009) and only from D14 in phototype III volunteers (N = 9; +17%; P = 0.011). These results suggest that the combination of Porphyra umbilicalis, Polypodium leucotomos, and vitamins C and E could strengthen the photoprotection capacity of individuals already protecting themselves by external means.
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