Abstract
Diurnal Preference Contributes to Maximal UVB Sensitivity by the Hour of the Day in Human Skin In Vivo
Highlights
In hairless mouse skin studies, it has been demonstrated that the time of day of ultraviolet radiation (UVR) exposure influences the erythemal response, sunburn-induced apoptosis, p53 formation, and repair of DNA photoproducts, suggesting that the circadian clock plays a role in these UVR-induced responses (Gaddameedhi et al, 2015)
We showed earlier that after exposure to narrow-band (NB) ultraviolet B (UV-B) radiation, the summarized evening erythema index (EI) scores were higher than the Journal Pre-proof morning scores, suggesting that the human skin is more vulnerable to UVR in the evening in vivo (Nikkola et al, 2018)
Our present study reports the outcome of NB UV-B minimal erythemal dose (MED) phototesting in the morning vs. evening, being performed 12 hours apart, and defines the erythema response of the skin in 36 volunteers with Fitzpatrick’s skin phototype II to III (Fitzpatrick, 1988)
Summary
Diurnal preference and UV-B radiation sensitivity Annina Raita1,2*, Iina-Maria Häggqvist1,3*, Heli Joronen1,2,3, Veera Nikkola1,2, Riitta HuotariOrava4, Lasse Ylianttila5, Hannu Kautiainen6, Erna Snellman1,2,7, Rafael Pasternack1,2, Timo Partonen8 In hairless mouse skin studies, it has been demonstrated that the time of day of UVR exposure influences the erythemal response, sunburn-induced apoptosis, p53 formation, and repair of DNA photoproducts, suggesting that the circadian clock plays a role in these UVR-induced responses (Gaddameedhi et al, 2015). We showed earlier that after exposure to narrow-band (NB) ultraviolet B (UV-B) radiation, the summarized evening erythema index (EI) scores were higher than the Journal Pre-proof morning scores, suggesting that the human skin is more vulnerable to UVR in the evening in vivo (Nikkola et al, 2018).
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