Abstract
Objective To investigate the effects of of Xiangbin Recipe (XBR) on gastrointestinal motility in healthy individuals. Methods Included in this study were 40 healthy volunteers recruited between March 2014 and March 2015. These individuals were randomly divided to receive 200 ml XBR decoction (XBR group, n=30) or 200 ml placebo (placebo group, n=10) during the fasting state. The two groups of volunteers were monitored for gastrointestinal motility, in which we recorded the changes of interdigestive migrating motor complex (MMC) parameters at the gastric antrum, duodenum and jejunum before and after the intervention. Results Compared with baseline, treatment with XBR shortened the MMC cycle by about 36%, reduced the duration of MMC phase I by about 49%, and increased the duration of MMC phase Ⅱ by about 140% (all P 0.05). Compared with the placebo group after intervention, XBR group showed significantly shortened phase Ⅰ duration, prolonged phase Ⅱ duration, increased phase Ⅲ amplitude at the gastric antrum, increased phases Ⅱ and Ⅲ MI at duodenum, and increased phase Ⅱ amplitude and MI at jejunum (all P<0.05). Conclusion The traditional Chinese medicine XBR may show significant effects in promoting gastrointestinal motility in healthy individuals. Clinical trial registration Chinese Clinical Trial Registry, ChiCTR-OCS-13003561. Key words: Xiangbin Recipe; Gastrointestinal agents (TCD); Gastrointestinal motility
Published Version
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