Abstract
Plasma proteins labeled with ${\rm L}\text{-leucine-}1\text{-}{}^{14}{\rm C}$ have been given intravenously to adult male rats to study the effects of whole-body x-irradiation and the role of the gastrointestinal tract on catabolism of plasma proteins to14 CO2. Comparison of normal and irradiated eviscerated surviving rats reveals that substantial catabolism of ${\rm L}\text{-leucine-}1\text{-}{}^{14}{\rm C}\text{-labeled}$ plasma proteins to14 CO2 occurs in the absence of the liver, spleen, gastrointestinal tract, and pancreas. The overall effect of whole-body x-irradiation was to enhance the apparent extent of oxidation of14 C-labeled plasma proteins. Included for comparison are observations on the oxidation of a tracer dose or of a loading dose of ${\rm L}\text{-leucine-}1\text{-}{}^{14}{\rm C}$ in normal and irradiated eviscerated surviving rats.
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