Abstract
BackgroundIn osteoporotic vertebral compression fractures, supplementation using vitamin D preparations and maintenance of blood vitamin D level within the normal range are necessary for proper fracture union, enhancement of muscle strength, and maintenance of body balance. The purpose of this study is to investigate the effects of vitamin D supplementation on blood vitamin D level, pain relief, union time, and functional outcome in patients with osteoporotic vertebral compression fracture and vitamin D deficiency.MethodsOne hundred thirty patients who were deficient in blood vitamin D level and had osteoporotic vertebral compression fracture were divided into supplementation group and non-supplementation group. Initially, 3 months, 6 months, and 12 months after the injury, radiographs were taken to assess fracture union, and questionnaires were evaluated to evaluate the functional outcome and quality of life.ResultsThe mean age of the 130 patients (36 males and 94 females) was 74.75 ± 7.25 years. There were no statistically significant differences in initial severity of low back pain, functional outcome, and quality of life between the insufficient group and the deficient group (all p values were > 0.05). There was no significant time-by-group interaction between the supplementation group and the non-supplementation group (p = 0.194). In terms of SF-36 physical component score, there was no significant time-by-group interaction between the supplementation group and the non-supplementation group (p = 0.934).ConclusionsFracture union was achieved in all patients regardless of serum vitamin D level, and there were significant improvements in severity of low back pain, functional outcome, and quality of life over 12 months in patients with osteoporotic vertebral compression fracture. Short-term vitamin D supplementation of patients with osteoporotic vertebral compression fracture and deficiency of vitamin D did not result in significant differences in fracture union status, functional outcome, and quality of life between the supplementation groups and the non-supplementation groups of patients.
Highlights
Osteoporotic fractures in the elderly refer to pathological fractures that occur even with minor trauma as a result of a decrease in bone mineral density (BMD) and low bone quality
The aim of this study is to investigate the effects of vitamin D supplementation on blood vitamin D level, pain relief, union time, and functional outcome in patients with osteoporotic vertebral compression fracture (OVCF) and vitamin D deficiency
Patient population After approval was granted by the Institutional Review Board and informed consent was obtained from the participants, we included 130 patients with OVCF who visited our clinic between January 2019 and January 2020 in this study based on the selection criteria (Table 1)
Summary
Osteoporotic fractures in the elderly refer to pathological fractures that occur even with minor trauma as a result of a decrease in bone mineral density (BMD) and low bone quality. Vitamin D deficiency is known to be associated with fragility fractures, osteoporosis, osteoporotic fractures, muscle weakness, and body balance. Other studies report that calcium and vitamin D supplementation is important for osteoporosis treatment in patients who are deficient in calcium and vitamin D. In osteoporotic vertebral compression fractures, supplementation using vitamin D preparations and maintenance of blood vitamin D level within the normal range are necessary for proper fracture union, enhancement of muscle strength, and maintenance of body balance. The purpose of this study is to investigate the effects of vitamin D supplementation on blood vitamin D level, pain relief, union time, and functional outcome in patients with osteoporotic vertebral compression fracture and vitamin D deficiency
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