Abstract

Oral inhalation of aerosolized drugs has be widely applied in healing the affected body organs including lesions of the throat and lungs and it is more efficient than those conventional therapies, such as intravenous drip, intramuscular injection and external topical administration in the aspects of the dosage reduction and side effects of drugs. Nevertheless, the traditional atomization devices always exhibit many drawbacks. For example, non-uniformed atomization particle distribution, the instability of transient atomization quantity and difficulties in precise energy control would seriously restrict an extensive use of atomization inhalation therapy. In this study, the principle of intra-hole fluctuation phenomenon occurred in the hole is fully explained, and the produced volume change is also estimated. Additionally, the mathematical expression of the atomization rate of the atomizing device is well established. The mechanism of the micro-pump is further clarified, and the influence of the vibration characteristics of the atomizing film on the atomization behavior is analyzed theoretically. The curves of sweep frequency against the velocity and amplitude of the piezoelectric vibrator are obtained by the Doppler laser vibrometer, and the corresponding mode shapes of the resonance point are achieved. The influence of vibration characteristics on atomization rate, atomization height and atomization particle size are also verified by experiments, respectively. Both the experimental results and theoretical calculation are expected to provide a guidance for the design of this kind of atomization device in the future.

Highlights

  • At present, Corona Virus Disease 2019 (COVID-19) has widely swept the whole world, it caused serious economic losses and casualties [1,2,3]

  • 5 Conclusions In present study, the influences of vibration characteristics on the atomization performance of the medical piezoelectric atomization device induced by intra-hole fluctuation were systematically investigated

  • The main conclusions can be drawn as follows: (1) The intra-hole fluctuation phenomenon in the hole is explained in details, in which the variation in volume caused by the intra-hole fluctuation phenomenon is deduced

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Summary

Introduction

Corona Virus Disease 2019 (COVID-19) has widely swept the whole world, it caused serious economic losses and casualties [1,2,3]. Moody et al [20] found that the vibration mesh atomization device has better therapeutic effect than the traditional jet nebulizer device in the treatment of pediatric asthma, which can significantly reduce the incidence rate of children Both the atomization rate and particle size are demonstrated to play pronounced roles in the inhalation therapy. Various vibration modes will occur under different resonance points, which can influence the vibration amplitude of the atomizer, affecting the deformation of the micro cone hole, and affecting the atomization amount and atomization particle size It is of great significance and meaningful to study the vibration characteristics of the atomizer

Experimental of Vibration Characteristics of Piezoelectric Vibrator
Conclusions
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