Abstract
Objective To evaluate the effects of two diuretic drugs on the ascites of liver cancer patients after hepatectomy. Methods One hundred and ten patients with liver cancer who planned to undergo hepatectomy were selected and were divided into experimental group and control group according to the random number table method, with 55 patients in each group. All patients were given routine treatment that patients in experimental group received 100 mg spironolactone tablets, 40 mg furosemide tablets, once a day; patients in control group were given 100 mg spironolactone tablets, 2 times a day, while administrated 40 mg furosemide tablets, once a day. The diuretic index and serum sodium, serum creatinine, albumin, adverse reactions, blood potassium, blood urea nitrogen, liver function index and the effectiveness of diuretic treatment in the two groups were observed and compared. Results After treatment, the number of micturition in experimental group was significantly lower than that in control group at night [(2.3±0.7) times vs. (3.0±0.8) times], the difference was statistically significant (t=2.530, P=0.013). After treatment, the levels of blood urea nitrogen, blood potassium, blood sodium and serum albumin were significantly improved in the two groups, and the differences were statistically significant (all P<0.05). After treatment, the liver function indexes of the two groups were significantly improved (P<0.05). There was no significant difference in the incidence of adverse reactions between experimental group and control group (76.4% vs. 70.9%, χ2=0.421, P=0.516). Conclusions The two protocols of diuretic drugs both can significantly reduce the incidence of ascites in patients with liver cancer after hepatectomy. The incidence of complications was also reduced. But the regimen, taking 40 mg furosemide and 100 mg spironolactone once a day, can significantly reduce the frequency of urination at night, it is worthy of clinical application. Key words: Hepatocellular carcinoma; Hepatectomy; Ascites; Spironolactone; Furosemide
Published Version
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