EFFECTS OF TURMERIC (CURCUMA LONGA L.) RHIZOME EXTRACT ONLUNGHISTOLOGICAL STRUCTUREIN MICE(MUSMUSCULUSL) INDUCEDNICOTINE

Abstract

Nicotine is an alkaloid compound found in tobacco leaves. The use of nicotine in a long period can cause lung damage.The aim of this study was to determine the effect of giving turmeric extract (Curcuma longa L.) on lung histological structure in nicotine-induced mice. In this study, 25 male mice were divided into 5 groups. Group 1 was a negative control group without nicotine-induced and turmeric extract. Group 2 was a positive control group induced by nicotine without turmeric rhizome extract, groups 3, 4 and 5 were groups exposed to nicotine followed by giving turmeric extract at doses of 0,98, 19,6 dan 29,4 mg/kg BW. The dose of nicotine given was 2.5 mg/kg BW, given intraperitoneally for 28 days. Turmeric extract was given as gavage for 14 days. The results showed that nicotine exposure resulted in an increase in mucosal thickness of the bronchioles and alveolar septa of mice. The administration of turmeric rhizome extract resulted in a decrease in the thickness of the bronchial mucosa and alveolar septa. Giving turmeric extract at a dose of 29,4 mg/kg BW resulted in a decrease in the thickness of the bronchial mucosa and alveolar septa. The conclusion of this study is that the 29,4 mg/kg BW dose of turmeric extract is effective in repairing histological damage to lung tissue in mice.