Abstract
Investigations into the effects of tumor bearing and protein depletion on wound breaking strength (WBS), serum protein content, and scar collagen production were performed in the rat. Animals were fed either regular diet (RD) or protein-depleted diets (PD) prior to or following wounding. Animals fed PD postwounding consistently lost weight, had reduced WBS, lower serum proteins, and reduced scar [ 3H]hydroxyproline content at 14 and 21 days whether they were on RD or PD diets prewounding. Animals fed PD prewounding and RD following wounding approached control values of WBS and scar [ 3H]hydroxyproline content by 21 days. Tumor bearing (TB) animals on RD manifested weight loss, reduced WBS, and hypoproteinemia by Day 21, compared to non-tumor (NTB) animals on RD but fed to pair the carcass weight of TB animals. In order to achieve comparable reductions in WBS and serum albumin levels seen in TB animals, we imposed severe metabolic restrictions on NTB animals by PD diets. This eventuated in weight loss two times greater than the TB animals as well as hypoproteinemia. Reductions in WBS were accompanied by wound compliance changes suggesting decreased compliance in TB animals.
Published Version
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