Abstract
Objective: To conduct a systematic review of the literature describing male mammals' reproductive and sexual parameters exposed to the biocide TBT. Method: A formal computer-assisted search was performed independently by two authors using five online databases and keywords. A manual search of the reference list of the articles found for relevant original articles was also used. We initially identified potentially eligible publications related to the topic of interest through this procedure. The last systematic search resulted in adequate data on TBT toxicity in the mammalian male reproductive tract. Results: Decreases in testicular, epididymal, prostate and seminal vesicle weights were observed at higher TBT ranges. Decreases in serum testosterone levels were reported in some studies, with some histological changes in the surveyed tissues and decreased transcriptional expressions of steroidogenic enzymes. Notably, there were significant reductions in sperm count and motility and increased abnormalities. Conclusions: Further studies are needed to elucidate the precise manner of TBT's deleterious mechanisms of action on the spermatogenesis process. Therefore, a comprehensive survey of TBT levels in food and water sources should also be conducted better to protect susceptible populations from potentially deleterious reproduction effects.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
