Effects of Transient and Prolonged Flashing Light Stimulation on the Cytochrome Oxidase Module System in Layer IV of the Primary Visual Cortex of Kittens

Abstract

Cytochrome oxidase spots in layer IV of field 17 of the primary visual cortex were studied in kittens aged 33, 49, and 93 days, stimulated with a light flashing at a frequency of 15 Hz. The kittens of one group received stimulation from the moment of eye opening until euthanasia (prolonged stimulation); other groups received stimulation for eight days starting from ages 26, 42, or 85 days (transient stimulation), again until euthanasia. Both types of stimulation were found not to alter the geometrical characteristics of cytochrome oxidase spots, but led to significant increases in the contrast of spots located in the splenial gyrus. Increases in spot contrast in the lateral gyrus occurred only after prolonged stimulation to age 93 days or after transient stimulation from age 26 days to age 33 days. Thus, stimulation of kittens of different ages with a light flashing at a frequency of 15 Hz led to structural-metabolic changes in the primary visual cortex. These changes were apparent to different extents in areas of the cortex responsible for central and peripheral vision. This may be explained, firstly, by the predominant activation of the Y conducting channel of the visual system and, secondly, by the increase in dominance of the contralateral input to the primary visual cortex.