Abstract
Repeated topical administration of ouabain has been shown to induce a hypodynamic state in both normal and buphthalmic rabbit eyes. The fall in intraocular pressure is greater with increasing concentrations of ouabain. When 0·25% or 0·125% ouabain solutions are used on buphthalmic rabbits, a lowering of the intraocular pressure is observed within 2 hr. This effect persists for about 3 days. Responsiveness does not appear reduced when tests are repeated frequently in the same animal. The histological evidence in buphthalmic eyes suggests that the elevated intraocular pressure in these eyes is most likely related to a deficient drainage mechanism and that lowering of the intraocular pressure by a drug such as ouabain is due, primarily, to an inhibition of aqueous humor secretion.
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