Abstract
Effects of topical doxycycline on inflammatory markers in periodontal disease
Highlights
Effects of topical doxycyclineAlmost all microorganisms related to periodontal disease are sensitive to tetracyclines, because of this we use doxycycline, which is a second-generation semi-synthetic derivative, as an adjunct to periodontal treatment [1,2,3,4].The literature shows heterogeneous results, there are studies that show the effect of tetracyclines, especially second-generation ones, on the improvement of both clinical and biochemical parameters [58]
The biochemical reevaluation shows, after three months, after nonsurgical periodontal treatment and according to the Brunner-Langer non-parametric model, as fundamental findings, the reduction of serum fibrinogen levels in the group treated with doxycycline 364.5 ± 93.2 versus 347.0 ± 100.8 (p = 0.077), while in the control group the serum levels increased 314.8 ± 63.7 versus 320.4 ± 65.1 (p = 0.305)
Our results can be interpreted by the presence of a residual inflammatory load, a result of the aggression caused by periodontal treatment, which would lead to an increase in acute phase reactants, including fibrinogen, and given the immunomodulatory properties of doxycycline, the final balance results in a decrease in the values of serum levels
Summary
The literature shows heterogeneous results, there are studies that show the effect of tetracyclines, especially second-generation ones, on the improvement of both clinical and biochemical parameters [58]. According to this line of thinking, there are studies that use slow release microspheres of minocycline or fibers with tetracycline [9,10]. The heterogeneity of the results could be explained because of the short-term execution of the studies, almost all of them are considered three months It has been suggested, in some studies that can obtain results even with statistical significance, that it would require a longer-term monitoring study execution, between 6 and 12 months or the repetition of doses throughout the treatment to optimize the response [15,16]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
