Abstract
Objective To observe the effects of Tiaozhi-Tongluo decoction combined with atorvastatin tablets on type 2 diabetes mellitus and lipid metabolism in patients with hyperlipidemia. Methods All patients were recruited into a control group and an observation group. Patients in both groups were performed diet control, reasonable exercise, and routine oral sulfonylureas and biguanides to make glucose level in a normal range. The control group was treated with atorvastatin tablets, 20 mg/d. While the observation group was treated with atorvastatin tablets plus Tiaozhi-Tongluo decoction. After both groups were treated for 6 months, the blood glucose and blood lipid level were detected for the evaluation of clinical curative effect. Results The total effective rates in the observation group and the control group were 87.5% (56/64)and 73.0% (46/63), respectively, the difference was statistically significant (χ2=4.213, P=0.040). The serum levels of total cholesterol (4.31 ± 1.11 mmol/L vs. 5.62 ± 1.34 mmol/L, t =6.004) and triglyceride (1.73 ± 0.53 mmol/L vs. 2.57 ± 1.01 mmol/L, t =5.855) in the observation group were significant lower than those in the control group. The levels of fasting plasma glucose (6.31 ± 1.64 mmol/L vs. 7.21 ± 1.71 mmol/L, t =3.027) , 2-h postchallenge plasma glucose (8.81 ± 1.39 mmol/L vs. 9.69 ± 1.55 mmol/L, t =3.370), and glycosylated hemoglobin (6.79% ± 1.61% vs. 7.96% ± 1.72%, t=3.958) in the observation group after treatment were significantly decreased than the control group (P<0.01). Conclusion Tiaozhi-Tongluo decoction combined with atorvastatin can reduce serum total cholesterol and triacylglycerol, and it is superior to atorvastatin alone in reducing lipidemia in type 2 diabetes mellitus patients with hyperlipidemia. Key words: Diabetes mellitus, type 2; Hyperlipidemias; Anticholesteremic agents; Treatment outcome; Atorvastatin; Tiaozhi-Tongluo decoction
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