Abstract
Parkinson is a common neurodegenerative disorder, characterized by motor and non-motor symptoms, including abnormalities in the gut function, which may appear before the motor sign. To date, there are treatments that can help relieve Parkinson’ disease (PD)-associated symptoms, but there is no cure to control the onset and progression of this disorder. Altered components of the gut could represent a key role in gut-brain axis, which is a bidirectional system between the central nervous system and the enteric nervous system. Diet can alter the microbiota composition, affecting gut-brain axis function. Gut microbiome restoration through selected probiotics’ administration has been reported. In this study, we investigated the effects of the novel formulation SLAB51 in PD. Our findings indicate that this probiotic formulation can counteract the detrimental effect of 6-OHDA in vitro and in vivo models of PD. The results suggest that SLAB51 can be a promising candidate for the prevention or as coadjuvant treatment of PD.
Highlights
Neurodegenerative disease etiology is still unclear, but different contributing factors, such as lifestyle and genetic factors are involved [1]
Parkinson is a common neurodegenerative disorder, characterized by motor and non-motor symptoms, including abnormalities in the gut function, which may appear before the motor sign
Parkinson’ disease (PD) patients present motor symptoms, including tremor, rigidity, postural instability, and bradykinesia, accompanied by non-motor symptoms, such as depression, abnormalities in the gut function, pain, hyposmia, which may appear before the motor sign [13,14,15]
Summary
Neurodegenerative disease etiology is still unclear, but different contributing factors, such as lifestyle and genetic factors are involved [1]. Parkinson is a common neurodegenerative disease, characterized by loss of dopaminergic neurons and α-synuclein intracellular accumulation, named Lewy bodies [2]. Numerous studies have indicated that the underlying mechanisms of Parkinson’s disease (PD) involve the inflammatory pathway and the oxidative stress, characterized by an imbalance between protective and detrimental function [3,4,5]. Diet can alter the microbiota composition, affecting gut-brain www.aging-us.com axis function [12, 16]. The loss of enteric dopaminergic neurons induces higher expression of pro-inflammatory cytokines [18]. The intestinal tract of PD patients shows a different gut microbiota compared to healthy individuals, with reduced levels of Prevotellaceae and abundance of Enterobacteriaceae [12, 19, 20], this dysbiosis is more evident in the severe PD phenotype
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
