Effects of the nutraceutical myricetin on liver health: a systematic review

Abstract

This article presents a systematic review addressing the effects of the nutraceutical myricetin on liver health. Nutraceuticals are natural or bioactive substances known for their health benefits and their crucial role in the prevention and treatment of liver diseases. In this context, myricetin, a flavonoid found in various food sources, emerges as a relevant nutraceutical for liver health. This review analyzes 20 preclinical studies demonstrating the benefits of myricetin on liver health, including improvement in Non-Alcoholic Fatty Liver Disease (NAFLD), attenuation of liver injuries, and even its therapeutic potential in the treatment of liver cancer in animal models. However, it was observed that there is a lack of clinical trials that fully explore the potential of myricetin as a nutraceutical. Most existing research is based on preclinical studies, such as animal or cell experiments. Therefore, there is a need for clinical studies to assess the efficacy of myricetin in humans. Furthermore, future research approaches are suggested, including investigating the mechanisms of action of myricetin, determining optimal doses and long-term safety, and developing dietary supplements.