Abstract

Effects of the Mixture of <i>Erigeron floribundus</i> (<i>Asteraceae</i>) and <i>Tragia benthamii</i> (<i>Euphorbiaceae</i>) on the Growth and Architecture of Estrogen-Sensitive Sexual Organs

Highlights

  • Nature has been a great source for thousands of therapeutic molecules and continues to play a key role in primary health care worldwide, and especially in developing countries for a long time [1]

  • We showed that the aqueous extract of the mixture of Erigeron floribundus and Tragia benthamii (AEMEFTB) suppresses the endometrium growth in rats with experimental endometriosis, possesses antioxidant, anti-inflammatory activities and regulates plasmatic sexual hormone concentrations [9]

  • The effect was more expressed in females co-treated with AEMEFTB and estradiol with a significant increase (P < 0.05) observed in group receiving the higher dose of the plant (260 mg/kg + E2)

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Summary

Introduction

Nature has been a great source for thousands of therapeutic molecules and continues to play a key role in primary health care worldwide, and especially in developing countries for a long time [1]. Medicinal plants have increasingly gained public and professional acceptance due to their variety of active principles on one hand, and to progress in the understanding of the mechanisms by which they influence the biological processes and improve health quality on the other hand [2] Many of these medicinal plants contain phytoestrogens which could act either as estrogenic or anti-estrogenic agents depending on the dose, level of endogenous estrogen in the body and types of estrogen receptor [3] [4]. Tragia benthamii is a climbing herb of the Euphorbiaceae family, widely spread in west, central and South Africa It is traditionally used in Cameroon as an abortifacient, antimicrobial and infertility in women [8]. The mixture of these two species is traditionally used against pelvic pain, dysmenorrhea and female sexual dysfunctions in the West-Cameroon Region

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