Abstract
Objective. We studied prosexual effects of Eremomastax speciosa aqueous extract in male adult rats. Materials and Methods. 100 and 500 mg/kg of extract were administered orally (days 0, 1, 4, 7, 14, and 28 (posttreatment)). The sexual behavior of rats receiving a single dose (500 mg/kg) was also evaluated after pretreatment with Lω-NAME (10 mg/kg), haloperidol (1 mg/kg), or atropine (5 mg/kg). Controls received distilled water or testosterone enanthate (20 mg/kg/day/3 days (s.c.) before the test). Results. The extract (days 1–14) had no significant effect on mount, intromission, and ejaculation frequencies but on day 28 (14 days after treatment), it increased frequency of mounts and intromissions at 500 mg/kg. Mount, intromission, and ejaculation latencies reduced and postejaculatory intervals decreased but the effect did not persist 2 weeks after treatment. Extract prosex effects were greatly reduced by atropine and completely abolished by haloperidol, while Lω-NAME increased mount latency and potentiated extract effect on intromission and ejaculation latencies. Conclusion. In summary, E. speciosa extract can have positive effects on male sexual motivation and performance when administered for two weeks at the dose of 500 mg/kg. The effects (dopaminergic and/or cholinergic dependent) tend to appear during the posttreatment period.
Highlights
Treatment with the aqueous extract of E. speciosa had no statistically significant effect on the frequencies of mounts, intromissions, and ejaculations compared with animals treated with distilled water
On day 7, there were significant decreases in the mount latency, intromission latency, and ejaculation latency in rats receiving the extract at doses of 100 and 500 mg/kg (P < 0.05–P < 0.001) compared with day 0 and neutral control values (Tables 4, 5, and 6)
The computed male sexual behavior parameters including percentages of intromissions and ejaculations and index of libido were higher in the extract-treated animals compared with the distilled water controls
Summary
The male reproductive capacity is deficient in more than 50% of infertile couples. The causes of this decline in male reproductive capacity are numerous. Sexual disorders are among the most abundant; in addition, we can mention erectile dysfunction. About 150 million people worldwide suffer from erectile dysfunction [4]. This problem is likely to seriously hamper relations within a couple sometimes leading to divorce. The therapy involves the implantation of penile prostheses, intracavernous injections, and the use of certain pharmaceutical products (phosphodiesterase type V inhibitors) [5]. These pharmaceuticals favor the persistence of smooth muscle relaxation and the maintenance of erection [6]. Many plants (Montanoa tomentosa, Syzygium aromaticum, Massularia acuminata, and Fadogia agrestis) have the reputation of being
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